Scientists report first live birth of ‘chimeric’ monkey

Scientists have reported the first live birth of a “chimeric” monkey with stem cells taken from two embryos.

The embryos come from the same species of monkey – a crab-eating macaque – but are genetically distinct, the researchers said.

Chimeras are animals which contain groups of cells from two or more organisms with distinct types of DNA.

The baby monkey was born with “a high proportion” of donor cells – an average of 67% across the 26 different types of tissue, the scientists said.

This work could help us to generate more precise monkey models for studying neurological diseases as well as for other biomedicine studies

Zhen Liu, Chinese Academy of Sciences

The team in China, which has reported its work in the journal Cell, said its work has vast implications – from understanding more about devastating conditions such as motor neurone disease to finding ways to help conserve threatened species.

Senior author Zhen Liu, of the Chinese Academy of Sciences, said: “This is a long-sought goal in the field.”

He added: “This work could help us to generate more precise monkey models for studying neurological diseases as well as for other biomedicine studies.”

Chimeras are important for studying embryonic development, but research has largely been restricted to mice.

While monkeys have previously been created in the lab using donor cells, the researchers said these creatures had a much lower contribution of cells from embryos “so you cannot really call them chimeric animals”.

Professor Mu-Ming Poo, scientific director of the Institute of Neuroscience at the Chinese Academy of Sciences, said: “Just having several cells (that) are partially distributed all over the monkey body with no real formation or clear structures – you cannot really say that is chimera, strictly speaking.

“So the difference here is that now we have a very high level of contribution, with the donor cells forming a big part of the tissues (and) complex structures all over the monkey body.”

Stem cells are the body’s raw materials from which all other cells with specialised functions are generated.

For the study, the researchers used stem cell lines – a group of cells grown in a lab from a single stem cell – taken from a seven-day-old embryo.

These cells were then injected into embryos that were four to five days old.

The embryos were implanted into female macaques, resulting in 12 pregnancies and six live births.

Of the six, one baby monkey was born alive and managed to survive for 10 days.

Analysis showed this male newborn had donor stem cells in 26 different types of tissue, ranging from 21% to up to 92%.

Meanwhile, a foetus that was miscarried was also “substantially chimeric”, the researchers said, with stem cell-derived cells observed in the brain, heart, kidney, liver, and parts of the digestive system.

The researchers said that their work complied with the national ethical regulations in China.  (which mean nothing !)

The health of the monkey is still a problem. If we want to produce a monkey model, we have to have a better chimera that can live longer

Professor Mu-Ming Poo, Chinese Academy of Sciences

They said that as of next steps, they want to explore “mechanisms that underlie the survival of the embryos in the host animals”.

Prof Poo said: “The health of the monkey is still a problem.

“If we want to produce a monkey model, we have to have a better chimera that can live longer.”

WAV Comment – I (Mark) have had Multiple Sclerosis (MS) for the last 25 years, and it causes me now one hell of a lot of problems.  MS is a ‘neurological illness’ that happens, but which cannot be explained as to why in only some.

Animals DO NOT get MS.  As a sufferer I have always campaigned against the use of animals in MS research.  You don’t test Boeing 777 engines on a Spitfire; so if animals do not get MS, then why artificially ‘create’ it in animals and then test on them in them in some pathetic attempt to find a cure ? – for me, proper research would be to find out why animals don’t, and we do – and then move on from there.

Why test on animals when there are hundreds of human MS suffers waiting in line to put themselves forward as research tools in understanding more about this ? – surely they are better for the purpose.

20 years ago, 5 years after my diagnosis; I was informed that within the next 5 years the MS issue would be solved with the wonder cure.  20 further years on I / we are still waiting.

The reality is that this all comes down to money and funding research, whatever that really is.  Prof. Poo and his chums just want to exhaust the funding pot whilst never really achieving ‘that cure’; sufferers live in daily hope that a cure will be found for their illness.  The problem is that universities and departments like the national ethical regulations in China; ie probably a back street wet market type thing (where did they read Covid from ?) just keep on trying to justify animal research models without ever really making much progress.  I guess if animals die or are killed in ‘research’, they they can just chuck them in a bin and continue; probably a bit harder with proper human MS sufferers who really do have MS which is not artificially created in them as it is with non MS suffering with animals.

It really gets my goat that money is endlessly paid out for often pointless ‘research’ using animals.  I want to see positive, NON ANIMAL research; research that will provide real answers and hope fully which will lead to real cures.

This is what I mean; something positive without animal cruelty:

Current projects

Dr Hadwen Trust becomes Animal Free Research – Animal Free Research UK

Latest news – Animal Free Research UK

Always on the side of animals;

Regards Mark

Scientists report first live birth of ‘chimeric’ monkey (msn.com)